The co-rotating fully intermeshing twin-screw extruder is the primary production unit for compounding of polymer based materials. It also has had a long term presence in processing material in the chemical and food industry and more recently in pharmaceuticals. While this equipment celebrated its 50th anniversary several years ago and might be considered a “mature” technology, it has not experienced a decline in new developments as might be expected, but rather a significant number of advancements continue to evolve. This paper will highlight several significant developments of the past 10 to 15 years.
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Co-rotating Fully Intermeshing Twin-screw Compounding Extruders: Advancements for Improved Performance and Productivity
ANTEC 2011
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Feed Enhancement Technology for low bulk density material into co-rotating twin-screw compounding extruders
SPE 2011
Effectively feeding low bulk density material into a co-rotating twin-screw extruder has always been a challenge. However with the introduction of even finer particle size fillers (sub-micron in some cases) as well as new generations of polymer reactor resins, the issue has become even more problematic. This paper will review a new Feed Enhancement Technology (FET) that provides significant improvement for the introduction of fine particle / low bulk density materials into the extruder.
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Continuous extrusion as a tailor-made process for the production of aquatic feed
International Aquafeed Directory 2011
With an extrusion test lab that meets the special requirements for the production of aquatic feed, Coperion, well known by their former name Werner & Pfleiderer, offers manufacturers of aquatic feed and aquatic feed adaptations optimum conditions for the development of recipes and the optimization of production processes. This extrusion test lab is at the Coperion site in Stuttgart. It is equipped with a ZSK MEGAvolume PLUS twin screw extruder and the appropriate plant periphery.
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API dispersal through hot melt extrusion
Manufacturing Chemist
It has been estimated that 40–60% of drugs in development have poor bioavailability due to low aqueous solubility. This percentage is likely to increase in the future with the increased use of combinatorial chemistry in drug discovery targeting lipophilic receptors. Poor bioavailability results in increased development times, decreased efficacy, increased inter- and intrapatient variability and side-effects, and higher dosages that reduce patient compliance and increase cost. Thus, the ability to improve drug solubility and hence bioavailability through formulation and process technology is critical to improving a drug product’s efficacy and safety and reducing its cost.
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Extrusion zur Verkapselung von Wirkstoffen
Vitalstoffe
Verkapselte Wirk- und Zusatzstoffe gewinnen in vielen Anwendungsbereichen immer mehr Bedeutung. Sowohl die Pharma-, Kosmetik- und Chemiebranche als auch die Lebensmittelindustrie nützen die Verkapselung zum Schutz oder zur kontrollierten Freisetzung eines eingebetteten Kernmaterials.
